DHX58 Rabbit Polyclonal Antibody

CAT#: TA306480

Rabbit Polyclonal LGP2 Antibody

Product Images

Western blot analysis of LGP2 in rat kidney tissue lysate with LGP2 antibody at (A) 1 and (B) 2 ug/ml.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1 - 2 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: LGP2 antibody was raised against a 12 amino acid peptide from near the carboxy terminus of human LGP2.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: DEXH-box helicase 58
• Database Link:
  NP_077024
  Entrez Gene 80861 MouseEntrez Gene 303538 RatEntrez Gene 79132 Human
  UniProt ID Q96C10
• Background: Anti-viral innate immune responses are triggered by pathogen-associated molecular patters (such as the accumulation of intracellular nucleic acids resulting from virus infections) and represent the first line of defense against numerous infectious organisms. The Toll-like receptors (TLR) 3, 7, 8, and 9 are expressed in immune cells and function as transmembrane pattern recognition receptors to detect foreign nucleic acids. Other proteins that play similar roles, such as RIG-1 and MDA5 are members of a CARD-helicase family and are expressed in the cytoplasm. A third protein, LGP2, is similar to RIG-1 and MDA5, except for lacking a homologous CARD domain. It is thought to act as an element of negative-feedback regulation of intracellular antiviral signaling. At least four isoforms of LGP2 are known to exist.
• Synonyms: D11LGP2; D11lgp2e; LGP2; RLR-3

Reference Data

• Protein Pathways: RIG-I-like receptor signaling pathway