SLITRK2 Rabbit Polyclonal Antibody

CAT#: TA306524

Rabbit Polyclonal Slitrk2 Antibody

Product Images

Western blot analysis of Slitrk2 in mouse brain tissue lysate with Slitrk2 antibody at (A) 1 and (B) 2 ug/ml.

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  Immunohistochemistry of Slitrk2 in human brain tissue with Slitrk2 antibody at 2.5 ug/ml.

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  Immunofluorescence of slitrk2 in human brain tissue with slitrk2 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Slitrk2 antibody was raised against a 16 amino acid peptide from near the center of human Slitrk2.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: SLIT and NTRK like family member 2
• Database Link:
  NP_001137475
  Entrez Gene 245450 MouseEntrez Gene 309349 RatEntrez Gene 84631 Human
  UniProt ID Q9H156
• Background: SLIT and NTRK-like family 2 (Slitrk2) is a member a protein family consisting of six homologous transmembrane proteins (Slitrk1-6) that share two conserved leucine-rich repeat domains in the extracellular domain and have significant homology to Slit, a secreted axonal growth-controlling protein. These proteins are also homologous to trk neurotrophin receptors in their intracellular domains. Expression of Slitrk proteins is highly restricted to neural and brain tumor tissues, but varies within the family. For example, Slitrk2 is expressed primarily in neurons in the ventricular layer of the brain. Like every other Slitrk protein except Slitrk1, overexpression of Slitrk2 inhibited neurite outgrowth in cultured neurons. Deletion analysis indicated that the functional difference between Slitrk2 and Slitrk1 is within their intracellular domains. At least two isoforms of this protein are known to exist. This antibody is predicted to have no cross-reactivity to other Slitrk proteins.
• Synonyms: CXorf2; SLITL1

Reference Data

• Protein Families: Transmembrane