DDIT4 Rabbit Polyclonal Antibody

CAT#: TA306539

Rabbit Polyclonal RTP801 Antibody

Product Images

Western blot analysis of RTP801 in human kidney tissue lysate with RTP801 antibody at (A) 0.5 and (B) 1ug/ml.

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  Immunohistochemistry of RTP801 in mouse kidney tissue with RTP801 antibody at 5ug/ml.

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  Immunofluorescence of RTP801 in mouse kidney tissue with RTP801 antibody at 20ug/ml.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 0.5 - 1 ug/mL, ICC: 5 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: RTP801 antibody was raised against a 12 amino acid synthetic peptide from near the center of human RTP801. The immunogen is located within amino acids 90 - 140 of RTP801.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: DNA damage inducible transcript 4
• Database Link:
  NP_061931
  Entrez Gene 74747 MouseEntrez Gene 140942 RatEntrez Gene 54541 Human
  UniProt ID Q9NX09
• Background: RTP801 was initially identified as a gene induced by DNA damage, and later found to also be regulated by other cellular stresses such as hypoxia and glucocorticoid treatment. Recently, RTP801 has been shown to act as a mediator of tuberous sclerosis complex (TSC)-dependent regulation of the mammalian Target of Rapamycin (mTOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle. In response to energy stress, RTP801 inhibits mTOR function, resulting in dephosphorylation of downstream targets such as ribosomal protein S6 kinase 1 and 4EBP1 and decreasing cell growth. Disregulation of RTP801 may thus contribute to human tumorigenesis.
• Synonyms: Dig2; REDD-1; REDD1

Reference Data

• Protein Pathways: mTOR signaling pathway