CAPS1 (CADPS) Rabbit Polyclonal Antibody

CAT#: TA306560

Rabbit Polyclonal CAPS1 Antibody

Product Images

Western blot analysis of CAPS1 in rat brain tissue lysate with CAPS1 antibody at (A) 0.5 and (B) 1 ug/ml. Below: Immunohistochemistry of CAPS1 in human brain with CAPS1 antibody at 5 ug/ml.

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  Immunohistochemistry of CAPS1 in human brain with CAPS1 antibody at 5 ug/ml.

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  Immunofluorescence of CAPS1 in human brain tissue with CAPS1 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 0.5 - 1 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: CAPS1 antibody was raised against a 20 amino acid peptide near the carboxy terminus of the human CAPS1.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: Ca2+ dependent secretion activator
• Database Link:
  NP_003707
  Entrez Gene 26989 RatEntrez Gene 27062 MouseEntrez Gene 8618 Human
  UniProt ID Q9ULU8
• Background: CAPS1 and its related protein CAPS2 encode novel neural/endocrine-specific cytosolic and peripheral membrane proteins. Both are essential components of the synaptic vesicle priming machinery and are required for the Ca2+-regulated exocytosis of secretory vesicles; CAPS-deficienct neurons contain no or very few fusion competent synaptic vesicles, causing a selective impairment of fast phasic transmitter release. CAPS1 acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate and is thought to be a specific regulator of large dense-core vesicle fusion. Numerous isoforms of CAPS1 are known to exist; the lower molecular weight bands seen in the immunoblot image are likely to be these isoforms. This CAPS1 antibody is predicted to be specific to CAPS1 and not recognize CAPS2.
• Synonyms: CADPS1; CAPS; CAPS1; UNC-31