ELOVL6 Rabbit Polyclonal Antibody

CAT#: TA306564

Rabbit Polyclonal ELOVL6 Antibody

Product Images

Western blot analysis of ELOVL6 in Human brain tissue lysate with ELOVL6 antibody at (A) 1 and (B) 2 ug/ml.

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  Immunohistochemistry of ELOVL6 in human brain with ELOVL6 antibody at 5 ug/ml.

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  Immunofluorescence of ELOVL6 in Human Brain tissue with ELOVL6 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: ELOVL6 antibody was raised against a 16 amino acid peptide near the amino terminus of the human ELOVL6.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: ELOVL fatty acid elongase 6
• Database Link:
  NP_001124193
  Entrez Gene 170439 MouseEntrez Gene 171402 RatEntrez Gene 79071 Human
  UniProt ID Q9H5J4
• Background: Lipogenesis is a key event in the energy storage system and is controlled by the transcription factor sterol regulatory element-binding protein (SREBP)-1. Elongation of very long chain fatty acids protein 6 (ELOVL6) is a member of fatty acyl-CoA elongase gene family that converts palmitic to stearic acid and it has been shown to be a target of SREBP-1, playing an important role in de novo synthesis of long-chain saturated and monosaturated fatty acids in conjunction with fatty acid synthase and stearoyl-CoA desaturase ELOVL6 was predicted to be important for tissue fatty acid composition. Recent studies suggest that inhibition of this elongase could be a new therapeutic approach for ameliorating insulin resistance, diabetes and cardiovascular risks, even in the presence of a continuing state of obesity.
• Synonyms: FACE; FAE; LCE

Reference Data

• Protein Families: Transmembrane
• Protein Pathways: Biosynthesis of unsaturated fatty acids