Calpain 6 (CAPN6) Rabbit Polyclonal Antibody

CAT#: TA306628

Rabbit Polyclonal CAPN6 Antibody

Product Images

Western blot analysis of CAPN6 in rat lung tissue lysate with CAPN6 antibody at (A) 0.5 and (B) 1 ug/ml.

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  Immunohistochemistry of CAPN6 in human lung tissue with CAPN6 antibody at 2.5 ug/ml.

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  Immunofluorescence of CAPN6 in Human Lung cells with CAPN6 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 0.5 - 1 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: CAPN6 antibody was raised against a 18 amino acid peptide from near the carboxy terminus of human CAPN6.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: calpain 6
• Database Link:
  NP_055104
  Entrez Gene 12338 MouseEntrez Gene 83685 RatEntrez Gene 827 Human
  UniProt ID Q9Y6Q1
• Background: Calpains make up a ubiquitously expressed, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. This large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes as their activation can be triggered by calcium influx and oxidative stress. Calpain 6 (CAPN6) is most similar to Calpain 5; the C-terminal region of CAPN6 lacks homology to the calmodulin-like domain of other vertebrate calpains. CAPN6 is thought to be involved in the regulation of microtubule dynamics and cytoskeletal organization. CAPN6 has also been recently identified as an HIV dependency factor (HDF), suggesting that CAPN6 may be an important drug target in HIV treatment.
• Synonyms: CalpM; CANPX; CAPNX; DJ914P14.1

Reference Data

• Protein Families: Druggable Genome, Protease