JPH3 Rabbit Polyclonal Antibody

CAT#: TA306683

Rabbit Polyclonal JPH3 Antibody

Product Images

Western blot analysis of JPH3 in Daudi cell lysate with JPH3 antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide.

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  Immunohistochemistry of JPH3 in human brain tissue with JPH3 antibody at 2.5 ug/ml.

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  Immunofluorescence of JPH3 in Human Brain cells with JPH3 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: JPH3 antibody was raised against a 18 amino acid peptide near the carboxy terminus of human JPH3.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: junctophilin 3
• Database Link:
  NP_065706
  Entrez Gene 57340 MouseEntrez Gene 307916 RatEntrez Gene 57338 Human
  UniProt ID Q8WXH2
• Background: Junctional complexes between the plasma membrane (PM) and endoplasmic/sarcoplasmic reticulum (ER/SR) are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. Junctophilins (JPs) are important components of the junctional complexes. JPs are composed of a carboxy-terminal hydrophobic segment spanning the ER/SR membrane and a remaining cytoplasmic domain that shows specific affinity for the PM. Four JPs have been identified as tissue-specific subtypes derived from different genes: JPH1 is expressed in skeletal muscle, JPH2 is detected throughout all muscle cell types, and JPH3 and JPH4 are predominantly expressed in the brain. In the CNS, both JPH3 and JPH4 are expressed throughout neural sites and contribute to the subsurface cistern formation in neurons. Mice lacking both JPH3 and JPH4 subtypes exhibit serious symptoms such as impaired learning and memory and are accompanied by abnormal nervous functions. A repeat expansion in JPH3 is associated with Huntington disease-like 2. At least two isoforms of JPH3 are known to exist.
• Synonyms: CAGL237; HDL2; JP-3; JP3; TNRC22

Reference Data

• Protein Families: Druggable Genome, Transmembrane