TOMM70A (TOMM70) Rabbit Polyclonal Antibody

CAT#: TA306698

Rabbit Polyclonal TOM70 Antibody

Product Images

Western blot analysis of TOM70 in rat brain tissue lysate with TOM70 antibody at (A) 1 and (B) 2 ug/ml.

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  Immunohistochemistry of TOM70 in mouse brain tissue with TOM70 antibody at 2.5 ug/ml.

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  Immunofluorescence of TOM70 in Mouse Brain cells with TOM70 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: TOM70 antibody was raised against a 15 amino acid peptide near the center of human TOM70.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: translocase of outer mitochondrial membrane 70
• Database Link:
  NP_055635
  Entrez Gene 28185 MouseEntrez Gene 304017 RatEntrez Gene 9868 Human
  UniProt ID O94826
• Background: The translocase of outer mitochondrial membrane (TOM) complex is a multisubunit complex involved in the recognition, unfolding, and translocation of preproteins into the mitochondria. TOM70, an important member of the TOM complex, contains a tetratricopeptide repeat domain similar to those found in cytosolic chaperones such as Hsp90 and Hsc70 and provides a docking site for these proteins. This interaction is thought to be a critical first step in the TOM70-dependent mitochondrial import, followed by contact between the preprotein and TOM70. After targeting to TOM70, preproteins are translocated through the outer membrane via the TOM40 import pore complex. The precise mechanism of how preproteins progress from TOM70 to TOM40 to full translocation is still unclear. At least two isoforms of TOM70 are known to exist.
• Synonyms: Tom70; TOMM70A

Reference Data

• Protein Families: Transmembrane