TREX1 Rabbit Polyclonal Antibody

CAT#: TA306702

Rabbit Polyclonal TREX1 Antibody

Product Images

Western blot analysis of TREX1 in human spleen tissue lysate with TREX1 antibody at (A) 0.5 ug/ml and (B) 1 ug/ml.

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  Immunohistochemistry of TREX1 in human spleen tissue with TREX1 antibody at 2.5 ug/ml.

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  Immunofluorescence of TREX1 in Human Spleen tissue with TREX1 antibody at 20 μgg/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 0.5 and 1 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: TREX1 antibody was raised against a 15 amino acid peptide near the center of human TREX1.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: three prime repair exonuclease 1
• Database Link:
  NP_057465
  Entrez Gene 22040 MouseEntrez Gene 100049583 RatEntrez Gene 11277 Human
  UniProt ID Q9NSU2
• Background: Trex1 (ATRIP) is the major human 3' to 5' exonuclease which is required for checkpoint signaling after DNA damage. It is ubiquitously expressed, binds to single stranded DNA coated with replication protein A that accumulates at sites of DNA damage and recruits the ataxia telangiectasia and Rad3 related protein (ATR), a checkpoint kinase, to sites of DNA damage and replication stress. Trex1 is required for ATR expression. This gene uses two different open reading frames. The upstream ORF encodes proteins which interact with ATR and localize to intranuclear foci induced by DNA damage and are essential components of the DNA damage checkpoint. The downstream ORF encodes proteins with 3' to 5' exonuclease activity and may be a subunit of human DNA polymerase III. Multiple transcript variants encoding different isoforms have been found. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis. TREX1 antibody will not cross-react with the related protein TREX2.
• Synonyms: AGS1; CRV; DRN3; HERNS

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cytosolic DNA-sensing pathway