IL16 Rabbit Polyclonal Antibody

CAT#: TA306708

Rabbit Polyclonal IL-16 Antibody

Product Images

Western blot analysis of IL-16 in rat brain tissue lysate with IL-16 antibody at (A) 1 ug/ml and (B) 2 ug/ml.

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  Immunohistochemistry of IL-16 in mouse brain tissue with IL-16 antibody at 2.5 ug/ml.

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  Immunofluorescence of IL-16 in mouse brain tissue with IL-16 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: IL-16 antibody was raised against a 20 amino acid peptide near the amino terminus of human IL-16.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: interleukin 16
• Database Link:
  NP_001165599
  Entrez Gene 16170 MouseEntrez Gene 116996 RatEntrez Gene 3603 Human
  UniProt ID Q14005
• Background: IL-16 was initially identified as a chemotactic cytokine, but is now known to possess a wide range of activities. Later studies have more fully characterized IL-16 as an immunomodulatory cytokine that contributes to the regulatory process of CD4+ T cell recruitment and activation at sites of inflammation in association with asthma and several autoimmune diseases. The precursor of IL-16 (pro-IL-16) is thought to be cleaved towards the C-terminal region by Caspase-3, releasing a 20 kDa active form that binds to and signals through CD4. Besides acting as a chemotactic cytokine, IL-16 is thought to also be involved in the regulation of T cell proliferation and multiple infectious, immune-mediated, and autoimmune inflammatory disorders including irritable bowel syndrome, systemic lupus erythematosus, and neurodegenerative disorders. At least two isoforms of IL-16 are known to exist; the longer isoform (also known as NIL-16) is detected only in neurons of the cerebellum and hippocampus. This antibody will only detect the NIL-16 isoform.
• Synonyms: LCF; NIL16; prIL-16; PRIL16

Reference Data

• Protein Families: Druggable Genome, Secreted Protein