DSCR1L1 (RCAN2) Rabbit Polyclonal Antibody

CAT#: TA306733

Rabbit Polyclonal RCAN2 Antibody

Product Images

Western blot analysis of RCAN2 in 3T3 cell lysate with RCAN2 antibody at (A) 1 and (B) 2 ug/mL.

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  Immunohistochemistry of RCAN2 in mouse brain tissue with RCAN2 antibody at 2.5 ug/mL.

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  Immunofluorescence of RCAN2 in mouse brain tissue with RCAN2 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: RCAN2 antibody was raised against a 14 amino acid peptide near the center of human RCAN2.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: regulator of calcineurin 2
• Database Link:
  NP_005813
  Entrez Gene 53901 MouseEntrez Gene 140666 RatEntrez Gene 10231 Human
  UniProt ID Q14206
• Background: Regulator of calcineurin 2 (RCAN2), also known as ZAKI4 and DSCR1L1, is expressed as two isoforms differing at their N-terminus. The longer of the two (isoform 1) is expressed exclusively in the brain, while isoform 2 is ubiquitously expressed, with highest expression in brain, heart, and muscle. Both isoforms bind to the catalytic subunit of calcineurin, a Ca++-dependent protein phosphatase involved in several neuronal functions, though their C-terminal region and inhibit calcineurin’s activity. Unlike isoform 1 of RCAN2, the expression of the second isoform is not induced by the thyroid hormone T3. RCAN2 is a member of a family of three endogenous calcineurin regulators that are located near the minimal supernumerary fragment of chromosome 21 in individuals with Down syndrome, suggesting that they play a role in this syndrome. Multiple isoforms of RCAN2 are known to exist.
• Synonyms: CSP2; DSCR1L1; MCIP2; RCN2; ZAKI-4; ZAKI4