LRFN1 Rabbit Polyclonal Antibody

CAT#: TA306738

Rabbit Polyclonal LRFN1 Antibody

Product Images

Western blot analysis of LRFN1 in human brain lysate with LRFN1 antibody at (A) 1 and (B) 2 ug/ml.

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  Immunohistochemistry of LRFN1 in mouse brain tissue with LRFN1 antibody at 2.5 ug/ml.

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  Immunofluorescence of LRFN1 in mouse brain tissue with LRFN1 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: LRFN1 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human LRFN1.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: leucine rich repeat and fibronectin type III domain containing 1
• Database Link:
  NP_065913
  Entrez Gene 80749 MouseEntrez Gene 365222 RatEntrez Gene 57622 Human
  UniProt ID Q9P244
• Background: LRFN1 is one of a family of five transmembrane glycoproteins that are highly expressed in neuronal tissues. LRFN proteins share leucine-rich repeat (LRR)-immunoglobulin-like (Ig)-fibronectin type III (Fn)-transmembrane domain structure with other members of the LRR-Ig-Fn protein superfamily such as the Slitrk family of proteins. Expression of LRFN1, -3, and -4 mRNA was detected in embryonic neuronal cells, while Lrfn2 and Lrfn5 expression was primarily restricted to more mature cells. LRFN1, -2, and -4 bound to PDZ domains of postsynaptic PSD95, re-distributing PSD95 to the cell periphery. It has been suggested that the Lrfn proteins play a role in the developing and/or mature vertebrate nervous system. At least two isoforms of LRFN1 are known to exist. This antibody is predicted to not cross-react with other members of the LRFN family.
• Synonyms: SALM2

Reference Data

• Protein Families: Transmembrane