CEP164 Rabbit Polyclonal Antibody

CAT#: TA306746

Rabbit Polyclonal CEP164 Antibody

Product Images

Western blot analysis of CEP164 in rat heart tissue lysate with CEP164 antibody at (A) 1 and (B) 2 ug/ml.

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  Immunohistochemistry of CEP164 in mouse heart tissue with CEP164 antibody at 5 ug/ml.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 5 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: CEP164 antibody was raised against an 18 amino acid peptide near the amino terminus of human CEP164.
• Formulation: PBS containing 0.02% sodium azide.
• Purification: Affinity chromatography purified via peptide column
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: centrosomal protein 164
• Database Link:
  NP_055771
  Entrez Gene 214552 MouseEntrez Gene 363055 RatEntrez Gene 22897 Human
• Background: CEP164 was initially identified as a centrosomal protein, but other studies have indicated that it also plays a role in the formation of primary cilia, the microtubule-based sensory antennae projecting from the surface of many eukaryotic cells as well as in DNA damage response acting as a mediator protein. CEP164 interacts with both ATR and ATM, proteins that trigger a number of cellular responses including the initiation of DNA damaged-induced cell cycle checkpoints. It is phosphorylated upon replication stress, ultraviolet (UV) radiation, and ionizing radiation; silencing of CEP164 significantly reduces the DNA damage-induced phosphorylation of several proteins in the DNA damage-activated signaling cascade and compromises cell survival after UV damage. At least two isoforms of CEP164 are known to exist.
• Synonyms: NPHP15