TNFAIP3 Rabbit Polyclonal Antibody

CAT#: TA306770

Rabbit Polyclonal TNFAIP3 Antibody

Product Images

Western blot analysis of TNFAIP3 in rat lung tissue lysate with TNFAIP3 antibody at (A) 1 and (B) 2 ug/ml.

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  Immunohistochemistry of TNFAIP3 in human lung tissue with TNFAIP3 antibody at 5 ug/ml.

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  Immunofluorescence of TNFAIP3 in Human Lung cells with TNFAIP3 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: TNFAIP3 antibody was raised against a 17 amino acid peptide near the center of human TNFAIP3.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: TNF alpha induced protein 3
• Database Link:
  NP_006281
  Entrez Gene 21929 MouseEntrez Gene 683206 RatEntrez Gene 7128 Human
  UniProt ID P21580
• Background: TNFAIP3, also known as A20, is located in chromosome band 6q23, a region that is often deleted in B cell lymphomas. Recently, it was identified as a tumor suppressor gene in Hodgkin lymphoma and several subtypes of non-Hodgkin lymphomas. TNFAIP3 was initially identified as a zinc-finger protein that is rapidly and transiently induced by TNF-a, inhibiting NF-kB-dependent gene expression, and protecting cells from TNF-a-cytotoxicity. Overexpression of TNFAIP3 also inhibits the TLR2- and TLR4-mediated interleukin-8 synthesis in airway epithelial cells, suggesting that TNFAIP3 also acts as a negative regulator of TLR-mediated inflammatory responses, thereby protecting the host against harmful over-responses to pathogens. At least two isoforms of TNFAIP3 are known to exist.
• Synonyms: A20; OTUD7C; TNFA1P2

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: NOD-like receptor signaling pathway