SH3BP4 Rabbit Polyclonal Antibody

CAT#: TA306780

Rabbit Polyclonal SH3BP4 Antibody

Product Images

Western blot analysis of SH3BP4 in rat lung tissue lysate with SH3BP4 antibody at (A) 1 and (B) 2 ug/ml.

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  Immunohistochemistry of SH3BP4 in human lung tissue with SH3BP4 antibody at 5 ug/ml.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 5 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: SH3BP4 antibody was raised against an 18 amino acid peptide from near the carboxy terminus of human SH3BP4.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: SH3 domain binding protein 4
• Database Link:
  NP_055336
  Entrez Gene 64634 RatEntrez Gene 98402 MouseEntrez Gene 23677 Human
  UniProt ID Q9P0V3
• Background: SH3BP4 was initially isolated as a novel cDNA using differential display analysis using cultured human corneal fibroblasts. The protein contains three Asn-Pro-Phe (NPF) motifs, an SH3 domain, a PXXP motif, a bipartite nuclear targeting signal, and a tyrosine phosphorylation site. SH3BP4 has been shown to interact with specific endocytic proteins such as clathrin, dynamin, and the transferrin receptor (TfR) and localizes to TfR-containing coated pits and vesicles. It is thought to be involved in cargo-specific control of clathrin-mediated endocytosis, specifically controlling the internalization of TfR. At least two isoforms of SH3BP4 are known to exist.
• Synonyms: BOG25; TTP

Reference Data

• Protein Families: Druggable Genome