Occludin (OCLN) Rabbit Polyclonal Antibody

CAT#: TA306787

Rabbit Polyclonal OCLN Antibody

Product Images

Western blot analysis of OCLN in human liver tissue lysate with OCLN antibody at 1ug/ml.

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  Immunohistochemistry of OCLN in mouse brain tissue with OCLN Antibody at 5ug/ml.

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  Immunohistochemistry of OCLN in human liver tissue with OCLN antibody at 2.5ug/ml.

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  Immunofluorescence of OCLN in Human Liver tissue with OCLN antibody at 20ug/ml.

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  Immunofluorescence of OCLN in human liver tissue with OCLN antibody at 20ug/ml.

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  Immunofluorescence of OCLN in mouse brain tissue with OCLN antibody at 20ug/ml.

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Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: OCLN antibody was raised against a 15 amino acid synthetic peptide from near the carboxy terminus of human OCLN. The immunogen is located within the last 50 amino acids of OCLN.
• Formulation: PBS containing 0.02% sodium azide.
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: occludin
• Database Link:
  NP_002529
  Entrez Gene 18260 MouseEntrez Gene 83497 RatEntrez Gene 100506658 Human
  UniProt ID Q16625
• Background: Tight junctions act as a semi-permeable barrier to the transport of ions, solutes, and water and are considered to function as a fence that divides apical and basolateral domains of plasma membranes. Tight junctions coordinate a variety of signaling and trafficking molecules regulating cell differentiation, proliferation, and polarity and contain a number of junctional proteins including Occludin, Claudins, junctional adhesion molecules (JAMs), as well as multiple scaffold proteins. Occludin, the first identified component of tight junction strands, is thought function as a signal transmitter in multiple signaling pathways and can associate with multiple kinases and phosphatases such as PI3-kinase and protein phosphatases 1 and 2A. At least two isoforms of OCLN are known to exist.
• Synonyms: BLCPMG; PPP1R115