STING (TMEM173) Rabbit Polyclonal Antibody

CAT#: TA306811

Rabbit Polyclonal MPYS Antibody

Product Images

Western blot analysis of MPYS in A-20 cell lysate with MPYS antibody at (A) 1 and (B) 2 ug/mL.

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  Immunocytochemistry of MPYS in A20 cells with MPYS antibody at 5 ug/mL.

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  Immunofluorescence of MPYS in A-20 cells with MPYS antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: MPYS antibody was raised against a 17 amino acid peptide near the carboxy terminus of human MPYS.
• Formulation: PBS containing 0.02% sodium azide.
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: transmembrane protein 173
• Database Link:
  NP_938023
  Entrez Gene 72512 MouseEntrez Gene 340061 Human
  UniProt ID Q86WV6
• Background: MPYS is a recently identified plasma membrane tetraspanner that is associated with major histocompatibility complex class II (MHC-II) and mediates its transduction of apoptotic signals. It has also been found to be associated with VISA, a mitochondrial protein that acts as an adaptor in virus-triggered signaling. MPYS also interacts with IRF3 and recruits the kinase TBK1 to the VISA-associated complex, acting as a critical mediator of virus-triggered IRF3 activation and interferon (IFN) expression. It is thought that the binding of nucleic acid to the innate immune protein RIG-I causes complex formation between RIG-I, VISA, and MPYS. This complex then recruits TBK1 to phosphorylate IRF3 which then directly activates IFN transcription. At least three isoforms of MPYS are known to exist.
• Synonyms: ERIS; hMITA; hSTING; MITA; MPYS; NET23; SAVI; STING

Reference Data

• Protein Pathways: Cytosolic DNA-sensing pathway, RIG-I-like receptor signaling pathway