JMJD1C Rabbit Polyclonal Antibody

CAT#: TA306830

Rabbit Polyclonal JMJD1C Antibody

Product Images

Western blot analysis of JMJD1C in human liver tissue lysate with JMJD1C antibody at (A) 1 and (B) 2 ug/ml.

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  Immunohistochemistry of JMJD1C in rat liver tissue with JMJD1C antibody at 2.5 ug/ml.

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  Immunofluorescence of JMJD1C in rat liver tissue with JMJD1C antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: JMJD1C antibody was raised against a 20 amino acid peptide from near the amino terminus of human JMJD1C.
• Formulation: PBS containing 0.02% sodium azide.
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: jumonji domain containing 1C
• Database Link:
  NP_004232
  Entrez Gene 108829 MouseEntrez Gene 171120 RatEntrez Gene 221037 Human
  UniProt ID Q15652
• Background: The jumonji domain containing 1C protein (JMJD1C) was initially discovered in silico, and later suggested to be a candidate gene for autism. Like the related proteins JMJD1A and JMJD1B, JMJD1C is a histone H3K9 demethylase implicated in the nuclear hormone receptor-based transcriptional regulation. JMJD1C mRNA is highly expressed in undifferentiated embryonic stem (ES) cells as well as pancreatic islet, diffuse-type gastric cancer, and other tissues and tumors. The JMJD1C gene promoter contain bHLH-, AP-1-, and POU5F1-binding sites, and as preferential expression of POU5F1 has been reported in ES cells, pancreatic islet, and diffuse-type gastric cancer, it has been suggested that POU5F1-mediated expression of JMJD1C reactivates previously silenced genes in ES cells and diffuse-type gastric cancer. At least three isoforms of JMJD1C are known to exist. This antibody will not cross-react with JMJD1A or JMJD1B.
• Synonyms: RP11-10C13.2; TRIP8

Reference Data

• Protein Families: Druggable Genome