KDM4A Rabbit Polyclonal Antibody

CAT#: TA306831

Rabbit Polyclonal JMJD2A Antibody

Product Images

Western blot analysis of JMJD2A in rat liver tissue lysate with JMJD2A antibody at (A) 1 and (B) 2 ug/ml.

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  Immunohistochemistry of JMJD2A in rat liver tissue with JMJD2A antibody at 5 ug/ml.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 5 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: JMJD2A antibody was raised against a 14 amino acid peptide from near the center of human JMJD2A.
• Formulation: PBS containing 0.02% sodium azide.
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: lysine demethylase 4A
• Database Link:
  NP_055478
  Entrez Gene 230674 MouseEntrez Gene 313539 RatEntrez Gene 9682 Human
  UniProt ID O75164
• Background: Members of the Jumonji domain 2 (JMJD2) family contain a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. The first member of this group, JMJD2A, is widely expressed in human tissues and cell lines and functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor. JMJD2A can also form a complex with the androgen receptor (AR), a transcription factor that is pivotal for the development of prostate cancer. Overexpression of JMJD2A stimulates AR function and this stimulation is dependent on JMJD2A catalytic activity, suggesting that JMJD2A might be a critical protein with roles in cell proliferation and oncogenesis.
• Synonyms: JHDM3A; JMJD2; JMJD2A; TDRD14A

Reference Data

• Protein Families: Druggable Genome, Transcription Factors