PROSAPIP1 (LZTS3) Rabbit Polyclonal Antibody

CAT#: TA306841

Rabbit Polyclonal Prosapip1 Antibody

Product Images

Western blot analysis of Prosapip1 in SK-N-SH cell lysate with Prosapip1 antibody at 1 ug/ml.

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  Immunohistochemistry of Prosapip1 in rat brain tissue with Prosapip1 antibody at 2.5 ug/ml.

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  Immunofluorescence of Prosapip 1 in rat brain tissue with Prosapip 1 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Prosapip1 antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human Prosapip1.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: -
• Database Link:
  NP_055546
  Entrez Gene 241638 MouseEntrez Gene 280670 RatEntrez Gene 9762 Human
  UniProt ID O60299
• Background: Prosapip1 is a binding partner of the postsynaptic density (PSD) protein ProSAP2/Shank3, a major scaffolding protein in excitatory brain synapses. Prosapip1 is thought to bind ProSAP2/Shank3 through ProSAP2/Shank3’s PDZ domain and link it in turn to the Spine-associated Rap-Gap (SPAR). Prosapip1 shares significant homology with another PSD protein, PSD-Zip70, with both coding for a Fez1 domain that can be found in a total of four related protein, forming a novel family of scaffolding molecules termed ‘Fezzins’. Recent studies show that Prosapip1 can be found in endocrine cells in which it is localized primarily in the hormone-storing compartment of these cells, suggesting that Prosapip1 may have other functions in non-neuronal cells.
• Synonyms: PROSAPIP1; RP5-1187M17.10