SIPA1L1 Rabbit Polyclonal Antibody

CAT#: TA306876

Rabbit Polyclonal SIPA1L1 Antibody

Product Images

Western blot analysis of SIPA1L1 in rat brain tissue lysate with SIPA1L1 antibody at (A) 0.5 and (B) 1 ug/ml.

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  Immunohistochemistry of SIPA1L1 in human brain tissue with SIPA1L1 antibody at 5 ug/ml.

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  Immunofluorescence of SIPA1L1 in human brain tissue with SIPA1L1 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 0.5 - 1 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: SIPA1L1 antibody was raised against a 16 amino acid peptide from near the amino terminus of human SIPA1L1.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: signal induced proliferation associated 1 like 1
• Database Link:
  NP_056371
  Entrez Gene 217692 MouseEntrez Gene 246212 RatEntrez Gene 26037 Human
  UniProt ID O43166
• Background: Signal-induced proliferation associated-like protein 1 (SIPA1L1) is a member of the SIPA1 family of RapGAPs. SIPA1L1 was initially identified as a binding partner and degradation target of the E6 oncoprotein of high-risk papillomaviruses. Recently, it was discovered that Casein kinase I epsilon (CKIe), a Wnt-regulated kinase that regulates Wnt/b-catenin signaling, also can bind to the carboxy-terminus of SIPA1L1. CKIe phosphorylates SIPA1L1, thereby reducing its stability and alleviating its inhibition of Rap1, a protein required for Wnt8/CKIe-mediated gastrulation during embryogenesis, suggesting SIPA1L1 plays important roles in embryo development as well as control of cell proliferation.
• Synonyms: E6TP1