BFAR Rabbit Polyclonal Antibody

CAT#: TA306918

Rabbit Polyclonal BFAR Antibody

Product Images

Western blot analysis of BFAR in human kidney tissue lysate with BFAR antibody at (A) 1 and (B) 2 ug/mL.

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  Immunohistochemistry of BFAR in mouse kidney tissue with BFAR antibody at 5 ug/mL.

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  Immunofluorescence of BFAR in mouse kidney tissue with BFAR antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: BFAR antibody was raised against a 14 amino acid peptide near the carboxy terminus of human BFAR.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: bifunctional apoptosis regulator
• Database Link:
  NP_057645
  Entrez Gene 67118 MouseEntrez Gene 304709 RatEntrez Gene 51283 Human
  UniProt ID Q9NZS9
• Background: The bifunctional apoptosis inhibitor (BFAR) is scaffold protein that integrates signaling components of the cells apoptosis-regulatory machinery. BFAR is a multidomain protein capable of inhibiting apoptosis induced by TNF-family death receptors ('extrinsic pathway') as well as mitochondria-dependent apoptosis ('intrinsic pathway'). Interaction of BFAR with Bcl-2 or Bcl-XL via a SAM domain may contribute to the anti-apoptotic properties of BFAR. In addition, BFAR contains a DED-like domain that is capable of suppressing apoptosis mediated at the receptor level. BFAR is also thought to be involved in the regulation of neuronal survival.
• Synonyms: BAR; RNF47

Reference Data

• Protein Families: Druggable Genome, Transmembrane