CALHM1 Rabbit Polyclonal Antibody

CAT#: TA306919

Rabbit Polyclonal CALHM1 Antibody

Product Images

Western blot analysis of CALHM1 in rat liver tissue lysate with CALHM1 antibody at (A) 1 and (B) 2 ug/mL.

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  Immunohistochemistry of CALHM1 in rat liver tissue with CALHM1 antibody at 5 ug/mL.

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  Immunofluorescence of CALHM1 in Rat Liver cells with CALHM1 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: CALHM1 antibody was raised against a 17 amino acid peptide near the amino terminus of human CALHM1.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: calcium homeostasis modulator 1
• Database Link:
  NP_001001412
  Entrez Gene 499367 RatEntrez Gene 546729 MouseEntrez Gene 255022 Human
  UniProt ID Q8IU99
• Background: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by a massive loss of neurons in several brain regions and by the presence of senile plaques comprised of aggregated amyloid-b (Ab) peptides produced by the endoproteolysis of the amyloid precursor protein (APP). The calcium homeostasis modulator 1 (CALHM1) is a recently identified multipass transmembrane glycoprotein that controls cytosolic Ca2+ concentration and Ab levels. While some studies suggest CALHM1 is significantly associated with risk of AD, other reports suggest there is no link. CALHM1 has been suggested to modulate the Ca2+-dependent proteolytic process of APP through controlling the level of cytosolic Ca2+.
• Synonyms: FAM26C

Reference Data

• Protein Families: Transmembrane