TCF3 / E2A (TCF3) Rabbit Polyclonal Antibody

CAT#: TA306926

Rabbit Polyclonal TCF3 Antibody

Product Images

Western blot analysis of TCF3 in Human brain tissue lysate with TCF3 antibody at 1 ug/mL in (A) the absence and (B) presence of peptide blocking.

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  Immunohistochemistry of TCF3 in rat liver tissue with TCF3 antibody at 5 ug/mL.

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  Immunofluorescence of TCF3 in rat brain tissue with TCF3 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: TCF3 antibody was raised against a 17 amino acid peptide near the amino terminus of human TCF3.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: transcription factor 3
• Database Link:
  NP_001129611
  Entrez Gene 21423 MouseEntrez Gene 171046 RatEntrez Gene 6929 Human
  UniProt ID P15923
• Background: The TCF3 gene, also called E2A, encodes two basic helix-loop-helix (bHLH) transcription factors, E12 and E47, through alternative splicing. These transcription factors are involved in mediating canonical Wnt signaling, which is very important in a diverse array of cellular functions such as stem cell proliferation, self-renewal, activation, fate determination, differentiation and aging and senescence. They bind beta-catenin and can act as transcriptional activators or repressors for Wnt target genes, and have been shown to regulate specific target genes during CNS development downstream of Wnt signaling. TCF3/Lef complexes are also known to play key roles in controlling cell fate lineages in multipotent skin stem cells.
• Synonyms: AGM8; bHLHb21; E2A; E47; ITF1; TCF-3; VDIR

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Induced pluripotent stem cells, Transcription Factors