ZSCAN4 Rabbit Polyclonal Antibody

CAT#: TA306927

Rabbit Polyclonal ZSCAN4 Antibody

Product Images

Western blot analysis of ZSCAN4 in mouse lung tissue lysate with ZSCAN4 antibody in (A) the absence and (B) presence of peptide blocking.

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  Immunohistochemistry of ZSCAN4 in rat lung tissue with ZSCAN4 antibody at 5 ug/mL.

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  Immunofluorescence of ZSCAN4 in Rat Lung tissue with ZSCAN4 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: ICC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: ZSCAN4 antibody was raised against a 18 amino acid peptide near the carboxy terminus of human ZSCAN4.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: zinc finger and SCAN domain containing 4
• Database Link:
  NP_689890
  Entrez Gene 201516 Human
  UniProt ID Q8NAM6
• Background: Zytotic genome activation (ZGA) is the first and most critical transition event from the maternal genetic to the embryonic genetic program and the major burst of ZGA occurs only in the late 2-cell stage. ZSCAN4 encodes a SCAN domain and four zinc finger domains and is expressed in late 2-cell embryos and embryonic stem cells. Loss-of-function studies using siRNA shows delays in the progression from the 2-cell to the 4-cell stage and subsequent embryo development. ZSCAN4 plays an important role in the preimplantation development. Also, ZSCAN4 is involved in telomere maintenance and long term genomic stability in ES cells, suggesting that ZSCAN4 may be of critical importance in maintaining pluripotency in replicating stem cells.
• Synonyms: ZNF494

Reference Data

• Protein Families: Transcription Factors