MINA53 (MINA) Rabbit Polyclonal Antibody

CAT#: TA306928

Rabbit Polyclonal MINA Antibody

Product Images

Western blot analysis of MINA in human heart tissue lysate with MINA antibody at (A) 1 and (B) 2 ug/mL.

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  Immunohistochemistry of MINA in mouse heart tissue with MINA antibody at 5 ug/mL.

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  Immunofluorescence of MINA in mouse heart tissue with MINA antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: MINA antibody was raised against a 15 amino acid peptide near the amino terminus of human MINA.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: MYC induced nuclear antigen
• Database Link:
  NP_001035998
  Entrez Gene 67014 MouseEntrez Gene 84864 Human
  UniProt ID Q8IUF8
• Background: MINA is nuclear localized, myc-inducible protein that is thought to play a role in mammalian cell proliferation. Treatment of cancer cells lines such as the colon cancer cell line SW680 with siRNA against MINA inhibits cell growth, demonstrating that MINA may be a potential therapeutic target. MINA regulates several genes related to cell adhesion and metabolism that have also been shown to be regulated by c-Myc, but also regulates other genes whose expression are not modulated by c-Myc such as EGFR, IL-6 and HGF. MINA has also been found to act as a repressor to IL-4 expression in T cells, indicating that it may also play a role in T cell differentiation and genetic variation in T helper type 2 bias.
• Synonyms: MDIG; MINA53; NO52; ROX

Reference Data

• Protein Families: Druggable Genome