LZTR2 (SEC16B) Rabbit Polyclonal Antibody

CAT#: TA306930

Rabbit Polyclonal LZTR2 Antibody

Product Images

Western blot analysis of LZTR2 in mouse kidney tissue lysate with LZTR2 antibody at 1 ug/mL.

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  Immunohistochemistry of LZTR2 in mouse kidney tissue with LZTR2 antibody at 5 ug/mL.

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  Immunofluorescence of LZTR2 in mouse kidney tissue with LZTR2 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: LZTR2 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human LZTR2.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: SEC16 homolog B, endoplasmic reticulum export factor
• Database Link:
  NP_149118
  Entrez Gene 89867 MouseEntrez Gene 89868 RatEntrez Gene 89866 Human
  UniProt ID Q96JE7
• Background: LZTR2, also known as RGPR-p117, is a member of the BTB-kelch superfamily and was initially described as a nuclear factor I (NFI) binding protein and transcriptional regulator of the regucalcin gene. LZTR2 is cytoplasmically localized but is thought to translocate to the nucleus, a process mediated by protein kinase C signaling following hormonal stimulation. Recent evidence has suggested that there is a strong correlation of single nucleotide polymorphisms of LZTR2 with obesity in the Japanese population similar to that seen with the TMEM18 gene and the GNPDA2, BDNF, FAIM2, and MC4R genes with obesity in Caucasian populations, suggesting LZTR2 may play a role in metabolism and obesity risk.
• Synonyms: LZTR2; PGPR-p117; RGPR; SEC16S