BCAS3 Rabbit Polyclonal Antibody
Other products for "BCAS3"
Specifications
Product Data | |
Applications | IF, IHC, WB |
Recommended Dilution | WB: 0.5 - 1 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL |
Reactivities | Human, Mouse, Rat |
Host | Rabbit |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | BCAS3 antibody was raised against an 18 amino acid peptide near the amino terminus of human BCAS3. |
Formulation | PBS containing 0.02% sodium azide. |
Concentration | 1ug/ul |
Purification | Affinity chromatography purified via peptide column |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Gene Name | breast carcinoma amplified sequence 3 |
Database Link | |
Background | The Breast carcinoma amplified sequence (BCAS3) gene is localized to 17q23, a region that is often amplified in breast cancers. Copy number gains at this region have also been reported in other tumors such as brain, lung, liver, testis and bladder. BCAS3 is thought to be an estrogen receptor (ER)-a co-activator that acts through PELP1, another ER-a that in turn activates BCAS3 expression. This may set up a positive feedback loop leading to ER-a signal amplification in the cell which may play a significant role in breast cancer. BCAS3 expression has also been observed in embryonic stem cells and vascular precursors, suggesting that it may also play a role in embryogenesis and tumor angiogenesis. |
Synonyms | GAOB1; MAAB |
Reference Data |
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