MYBPC2 Rabbit Polyclonal Antibody

CAT#: TA306943

Rabbit Polyclonal MYBPC2 Antibody

Product Images

Western blot analysis of MYBPC2 in mouse skeletal muscle tissue lysate with MYBPC2 antibody at (A) 1 and (B) 2 ug/ml.

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  Figure from citation: Western blot analysis of Mybpc2 protein level by using anti-Mybpc2 antibody in triceps muscle (Tr) of 10 and 20 months-old hemizygous male mice (MUT) and wild-type mice (WT). Dilution: 1:1000 View Citation

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  Immunohistochemistry of MYBPC2 in mouse skeletal muscle tissue with MYBPC2 antibody at 5 ug/mL.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 5 ug/mL
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: MYBPC2 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human MYBPC2.
• Formulation: PBS containing 0.02% sodium azide.
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: myosin binding protein C, fast type
• Database Link:
  NP_004524
  Entrez Gene 233199 MouseEntrez Gene 4606 Human
  UniProt ID Q14324
• Background: Myosin binding protein C (MYBPC) is a component of the thick filament of striated muscle, with the fast-type isoform designated MYBPC2. Both the fast-type and slow-type MYBPC protein contains seven immunoglobulin C2 motifs and three fibronectin type-III repeats. MYBPC2 is typically required for strong contractions and functions under anaerobic conditions. It is more similar to the cardiac isoform (MYBPC3) than to the slow-type isoform (MYBPC1) in terms of pCa50-indexed force development, length-independent cooperativity and length dependent activation. It has been suggested that in cardiac and fast muscle MYBPC2 contributes to an internal load, possibly by binding to actin via its N-terminal region.
• Synonyms: MYBPC; MYBPCF