PIK3CD Rabbit Monoclonal Antibody [Clone ID: EPR386]

CAT#: TA307256

Rabbit monoclonal antibody against PI3-kinase p110 subunit delta(clone EPR386)

Product Images

Western blot - PI 3 Kinase p110 delta antibody [EPR386]; All lanes : Anti-PI 3 Kinase p110 delta antibody [EPR386] at 1/1000 dilution.Lane 1 : Jurkat cell lysate.Lane 2 : Raji cell lysate.Lane 3 : K562 cell lysate.Lane 4 : RAW 264.7 cell lysate.Lane 5 : Rat brain tissue lysate.Lane 6 : Rat kidney tissue lysate.Lane 7 : Rat spleen tissue lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 119 kDa.

Specifications

Product Data

• Clone Name: EPR386
• Applications: WB
• Recommended Dilution: WB: 1:1000 - 1:10000; ICC: 1:100 - 1:250
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: A synthetic peptide corresponding to residues in human PI3-kinase subunit delta was used as an immunogen.
• Formulation: pH: 7.40
  Preservative: 0.01% Sodium azide
  Constituents: 50% Glycerol, 0.05% BSA
• Purification: Tissue culture supernatant
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 119 kDa
• Gene Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
• Database Link:
  NP_005017
  Entrez Gene 18707 MouseEntrez Gene 366508 RatEntrez Gene 5293 Human
  UniProt ID O00329
• Background: Phosphoinositide 3-kinases (PI3Ks) are a family of lipid kinases that are implicated in signal transduction. PI3Ks consists of two subunits; p85 and p10. The p85 subunit localize PI3Ks activity to the plasma membrane while the p110 subunit contains the catalytic domain of PI3Ks (1-2). Four isoforms of p110 has been found; the alpha, beta, gamma, and delta subunit (3). The delta isoform is predominantly expressed in leukocytes and has been shown to interact with p85 and GTP-bound Ras via its SH2/SH3 domain (4).
• Synonyms: APDS; IMD14; p110D; P110DELTA; PI3K
• Note: Is unsuitable for Flow Cyt,IHC-P or IP.

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Acute myeloid leukemia, Apoptosis, B cell receptor signaling pathway, Chemokine signaling pathway, Chronic myeloid leukemia, Colorectal cancer, Endometrial cancer, ErbB signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Focal adhesion, Glioma, Inositol phosphate metabolism, Insulin signaling pathway, Jak-STAT signaling pathway, Leukocyte transendothelial migration, Melanoma, mTOR signaling pathway, Natural killer cell mediated cytotoxicity, Neurotrophin signaling pathway, Non-small cell lung cancer, Pancreatic cancer, Pathways in cancer, Phosphatidylinositol signaling system, Progesterone-mediated oocyte maturation, Prostate cancer, Regulation of actin cytoskeleton, Renal cell carcinoma, Small cell lung cancer, T cell receptor signaling pathway, Toll-like receptor signaling pathway, Type II diabetes mellitus, VEGF signaling pathway