SOCS2 Rabbit Monoclonal Antibody [Clone ID: EPR2588(2)]

CAT#: TA307336

Rabbit monoclonal antibody against SOCS2(clone EPR2588(2))

Product Images

Western blot - SOCS2 antibody [EPR2588 (2)]; All lanes : Anti-SOCS2 antibody [EPR2588 (2)] at 1/1000 dilution.Lane 1 : MCF7 cell lysate.Lane 2 : NCCIT cell lysate.Lane 3 : K562 cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 22 kDa.

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  Figure from citation: Western Blot of SOCS2 protein level by using anti-SOCS2 antibody in human CRC and distant normal counterpart tissues. Dilution: 1:1000 View Citation

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  Immunocytochemistry/ Immunofluorescence - SOCS2 antibody [EPR2588 (2)]; Immunofluorescent staining of HeLa cells using TA307336 at 1/100 dilution.

Specifications

Product Data

• Clone Name: EPR2588(2)
• Applications: IF, WB
• Recommended Dilution: WB: 1:1000 - 1:10000; IP: 1:10 - 1:100; ICC/IF: 1:100 - 1:250
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: A synthetic peptide corresponding to residues near the N-terminus of human SOCS2 was used as an immunogen.
• Formulation: PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
• Purification: Tissue culture supernatant
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 22 kDa
• Gene Name: suppressor of cytokine signaling 2
• Database Link:
  NP_003868
  Entrez Gene 8835 Human
  UniProt ID O14508
• Background: SOCS2 is a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of SOCS2 can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10 and interferon (IFN)-gamma. SOCS2 is found to interact with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling. Knockout studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control (1).
• Synonyms: CIS2; Cish2; SOCS-2; SSI-2; SSI2; STATI2
• Note: Is unsuitable for Flow Cyt or IHC-P.

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Insulin signaling pathway, Jak-STAT signaling pathway, Type II diabetes mellitus