FADD Rabbit Monoclonal Antibody [Clone ID: EPR4415]

CAT#: TA307340

Rabbit monoclonal antibody against FADD(clone EPR4415)

Product Images

Western blot - FADD antibody [EPR4415]; All lanes : Anti-FADD antibody [EPR4415] at 1/1000 dilution.Lane 1 : A431 cell lysate.Lane 2 : Jurkat cell lysate.Lane 3 : HeLa cell lysate.Lane 4 : SKBR-3 cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 23 kDa.

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  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - FADD antibody [EPR4415]; Immunohistochemical staining of paraffin-embedded Human kidney tissue using TA307340 at a dilution of 1/100.

Specifications

Product Data

• Clone Name: EPR4415
• Applications: IHC, WB
• Recommended Dilution: WB: 1:1000 - 1:10000; IP: 1:10 - 1:100; IHC-P: 1:100 - 1:250; ICC: 1:100 - 1:250
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: A synthetic peptide corresponding to residues in human FADD was used as an immunogen.
• Formulation: PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: Fas associated via death domain
• Database Link:
  NP_003815
  Entrez Gene 14082 MouseEntrez Gene 266610 RatEntrez Gene 8772 Human
  UniProt ID Q13158
• Background: Fas-associating protein with death domain (FADD) is an adaptor protein involved in apoptosis induced by Fas, TNF-R1, and mitogen induced cell proliferation (1). FADD consists of a death domain (DD) at the C-terminal and death effector domain (DED) at the N-terminal (2). DD interacts with Fas and TNF-R1, which exposes the DED portion on the FADD. Unmasked DED binds to the DED of pro-caspase-8, which activates the cysteine protease cascade (3). The development of autoimmune lymphoproliferative (lpr) diseases has been linked to the inactivation of Fas-FADD interaction (4). In addition, a deficiency in FADD can inhibit TRAIL-induced cell apoptosis.
• Synonyms: GIG3; MORT1
• Note: Is unsuitable for Flow Cyt.

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Alzheimer's disease, Apoptosis, Pathways in cancer, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway