Ube1L (UBA7) Rabbit Monoclonal Antibody [Clone ID: EPR4270]

CAT#: TA307362

Rabbit monoclonal antibody against UBA7(clone EPR4270)

Product Images

Western blot - Ube1L antibody [EPR4270]; All lanes : Anti-Ube1L antibody [EPR4270] at 1/1000 dilution.Lane 1 : HepG2 cell lysate.Lane 2 : HL60 cell lysate.Lane 3 : HeLa cell lysate.Lane 4 : Jurkat cell lysate.Lane 5 : Fetal liver lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 112 kDa.

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  Immunocytochemistry/ Immunofluorescence - Ube1L antibody [EPR4270]; Immunofluorescent staining of HeLa cells using TA307362 at a dilution of 1/100.

Specifications

Product Data

• Clone Name: EPR4270
• Applications: IF, WB
• Recommended Dilution: WB: 1:1000 - 1:10000; IP: 1:10 - 1:100; FC: 1:10 - 1:100; ICC/IF: 1:100 - 1:250
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: A synthetic peptide corresponding to residues on the C-terminus in human UBA7 was used as an immunogen.
• Formulation: PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: ubiquitin like modifier activating enzyme 7
• Database Link:
  NP_003326
  Entrez Gene 74153 MouseEntrez Gene 7318 Human
  UniProt ID P41226
• Background: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBA7 (ubiquitin-like modifier activating enzyme 7) is a member of the E1 ubiquitin-activating enzyme family. This protein is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein.
• Synonyms: D8; UBA1B; UBE1L; UBE2
• Note: Is unsuitable for IHC-P.

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Parkinson's disease, Ubiquitin mediated proteolysis