NFAT1 (NFATC2) Rabbit Monoclonal Antibody [Clone ID: EPR2973]

CAT#: TA307580

Rabbit monoclonal antibody against NFAT1 (clone EPR2973 )

Product Images

Western blot - NFAT1 antibody [EPR2973]; All lanes : Anti-NFAT1 antibody [EPR2973] at 1/1000 dilution.Lane 1 : Jurkat cell lysate.Lane 2 : Ramos cell lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 100 kDa.Observed band size : 135 kDa.

Specifications

Product Data

• Clone Name: EPR2973
• Applications: WB
• Recommended Dilution: WB: 1:1,000 - 5,000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: A synthetic peptide corresponding to residues in human NFAT1 was used as an immunogen.
• Formulation: PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
• Purification: Tissue culture supernatant
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 100 kDa
• Gene Name: nuclear factor of activated T-cells 2
• Database Link:
  NP_001129493
  Entrez Gene 18019 MouseEntrez Gene 311658 RatEntrez Gene 4773 Human
  UniProt ID Q13469
• Background: Nuclear factor of activated T-cells, cytoplasmic 2 (NFAT1) belongs to the NFAT family of transcription factors that are expressed in most immune cell types, and play a central role in the transcription of cytokine genes, such as IL-2, IL-4, IL-5, IL-13, IFN-gamma, TNF-alpha, and GM-CSF. The activity NFAT proteins are regulated by the calcium/calmodulin-dependent phosphatase calcineurin, a target for inhibition by CsA and FK506 (1). NFAT1 is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the NFAT transcription complex. This complex plays a central role in inducing gene transcription during the immune response (2).
• Synonyms: NFAT1; NFATP
• Note: Does not react with Mouse, Rat

Reference Data

• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Axon guidance, B cell receptor signaling pathway, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, VEGF signaling pathway, Wnt signaling pathway