HSP90AA1 Rabbit Monoclonal Antibody [Clone ID: EPNCIR102]

CAT#: TA307631

Rabbit monoclonal antibody against Hsp90 Alpha(clone EPNCIR102)

Product Images

Western blot - Hsp90 alpha antibody [EPNCIR102]; All lanes : Anti-Hsp90 alpha antibody [EPNCIR102] at 1/1000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : Jurkat cell lysate.Lane 3 : SKBR3 cell lysate.Lane 4 : K562 cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 85 kDa.

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  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Hsp90 alpha antibody [EPNCIR102]; TA307631 at 1/50 dilution staining Hsp90 alpha in Human breast carcinoma by Immunohistochemistry, Paraffin-embedded tissue.

Specifications

Product Data

• Clone Name: EPNCIR102
• Applications: IHC, WB
• Recommended Dilution: WB: 1:1000 - 1:10000; IHC-P: 1:50 - 1:100
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: A synthetic peptide corresponding to residues in human Hsp90 Alpha was used as an immunogen.
• Formulation: PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
• Purification: Tissue culture supernatant
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 85 kDa
• Gene Name: heat shock protein 90kDa alpha family class A member 1
• Database Link:
  NP_001017963
  Entrez Gene 15519 MouseEntrez Gene 299331 RatEntrez Gene 3320 Human
  UniProt ID P07900
• Background: Heat shock protein 90 alpha (Hsp90 alpha) is a cytosolic homodimeric molecular chaperone that modulates the stability and/or transport of a diverse set of critical cellular regulatory, metabolism, organization, and signaling proteins (1). Hsp90 distinguishes itself from other chaperones by having most of its known substrates as signal transduction proteins; e.g. non activated steroid hormone receptors, several proto-oncogenic tyrosine and serine/threonine kinases, and actin (2). These substrates are brought into complex by a multiprotein hsp90/hsp70-based chaperone machinery to function in protein folding (3). Two isoforms correspond to the major and minor isoform, Hsp90 alpha and Hsp90 beta. Hsp90 beta is expressed constitutively to a high level in most tissues and is generally more abundant than Hsp90 alpha, whereas Hsp90 alpha is stress-inducible and overexpressed in many cancer cells (4).
• Synonyms: EL52; HSP86; Hsp89; HSP89A; Hsp90; HSP90A; HSP90N; HSPC1; HSPCA; HSPCAL1; HSPCAL4; HSPN; LAP-2; LAP2
• Note: Is unsuitable for Flow Cyt,ICC or IP.

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Antigen processing and presentation, NOD-like receptor signaling pathway, Pathways in cancer, Progesterone-mediated oocyte maturation, Prostate cancer