Rb (RB1) Rabbit Monoclonal Antibody [Clone ID: EP44(2)]

CAT#: TA307721

Rabbit monoclonal antibody against Rb (clone EP44(2) )

Product Images

Western blot - Rb antibody [EP44 (2)]; All lanes : Anti-Rb antibody [EP44 (2)] at 1/1000 dilution.Lane 1 : Jurkat cell lysates.Lane 2 : K562 cell lysates.Lysates/proteins at 10 ug per lane.Predicted band size : 106 kDa.

Specifications

Product Data

• Clone Name: EP44(2)
• Applications: WB
• Recommended Dilution: WB: 1:1000 - 1:2000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: A synthetic peptide corresponding to residues in human Rb was used as an immunogen.
• Formulation: PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: RB transcriptional corepressor 1
• Database Link:
  NP_000312
  Entrez Gene 19645 MouseEntrez Gene 24708 RatEntrez Gene 5925 Human
  UniProt ID P06400
• Background: Retinoblastoma tumor suppressor protein (Rb) is associated with DNA binding activity and is thought to play a significant role in controlling cell cycle progression during tumor growth (1, 2). Cell cycle-dependent phosphorylation by cdk's inhibits Rb binding, thus allowing cell cycle progression (3). Rb inactivation and cell cycle progression likely requires first phosphorylation by cyclin D-cdk4/6 followed by cyclin E-cdk2 phosphorylation (4).
• Synonyms: OSRC; p105-Rb; pp110; PPP1R130; pRb; RB
• Note: Is unsuitable for Flow Cyt,ICC,IHC-P or IP.

Reference Data

• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Bladder cancer, Cell cycle, Chronic myeloid leukemia, Glioma, Melanoma, Non-small cell lung cancer, Pancreatic cancer, Pathways in cancer, Prostate cancer, Small cell lung cancer