Desmocollin 2 (DSC2) Rabbit Polyclonal Antibody

CAT#: TA307897

Rabbit polyclonal antibody to Desmocollin 2 (desmocollin 2)

Product Images

Desmocollin 2 antibody [C1C2], Internal detects Desmocollin 2 protein by western blot analysis. Whole cell extracts (30 ug) was separated by 7.5 % SDS-PAGE, and blotted with Desmocollin 2 antibody [C1C2], Internal (TA307897) diluted by 1:500

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  Immunohistochemical analysis of paraffin-embedded OVCAR3 xenograft, using Desmocollin 2 (TA307897) antibody at 1:500 dilution.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: IHC:1:100-1:1000; WB:1:500-1:3000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant fragment corresponding to a region within amino acids 480 and 706 of Desmocollin 2 (Uniprot ID#Q02487)
• Formulation: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Concentration: lot specific
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 94 kDa
• Gene Name: desmocollin 2
• Database Link:
  NP_004940
  Entrez Gene 13506 MouseEntrez Gene 1824 Human
  UniProt ID Q02487
• Background: The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11. Alternative splicing results in two transcript variants encoding distinct isoforms. [provided by RefSeq]
• Synonyms: ARVD11; CDHF2; DG2; DGII; DSC3; III
• Note: Seq homology of immunogen across species: Mouse (80%)

Reference Data

• Protein Families: Transmembrane
• Protein Pathways: Arrhythmogenic right ventricular cardiomyopathy (ARVC)