IL12RB2 Rabbit Polyclonal Antibody
CAT#: TA307956
Rabbit polyclonal antibody to IL-12 Receptor beta2 (interleukin 12 receptor, beta 2)
Other products for "IL12RB2"
Specifications
Product Data | |
Applications | WB |
Recommended Dilution | WB:1:1000-1:10000 |
Reactivities | Human |
Host | Rabbit |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | Recombinant fragment corresponding to a region within amino acids 323 and 695 of IL-12 Receptor beta2 (Uniprot ID#Q99665) |
Formulation | 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. |
Concentration | lot specific |
Purification | Purified by antigen-affinity chromatography. |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Predicted Protein Size | 97 kDa |
Gene Name | interleukin 12 receptor subunit beta 2 |
Database Link | |
Background | The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. [provided by RefSeq] |
Synonyms | RP11-102M16.1 |
Note | Seq homology of immunogen across species: Dog (80%) |
Reference Data | |
Protein Families | Druggable Genome, Transmembrane |
Protein Pathways | Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway |
Documents
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