RAMP1 Rabbit Polyclonal Antibody

CAT#: TA307973

Rabbit polyclonal antibody to RAMP1 (receptor (G protein-coupled) activity modifying protein 1)

Product Images

Sample (30 ug of whole cell lysate). A: Hep G2. 12% SDS PAGE. TA307973 diluted at 1:1000.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB:1:500-1:3000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region within amino acids 84 and 148 of RAMP1 (Uniprot ID#O60894)
• Formulation: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Concentration: lot specific
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 17 kDa
• Gene Name: receptor activity modifying protein 1
• Database Link:
  NP_005846
  Entrez Gene 51801 MouseEntrez Gene 58965 RatEntrez Gene 10267 Human
  UniProt ID O60894
• Background: The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface. [provided by RefSeq]
• Synonyms: receptor (calcitonin) activity modifying protein 1; receptor (G protein-coupled) activity modifying protein 1; receptor-activity modifying protein 1
• Note: Seq homology of immunogen across species: Mouse (93%), Rat (93%), Xenopus Tropicalis (87%), Pig (86%), Guinea pig (80%)

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Vascular smooth muscle contraction