ACMSD Rabbit Polyclonal Antibody

CAT#: TA308027

Rabbit Polyclonal antibody to ACMSD (aminocarboxymuconate semialdehyde decarboxylase)

Product Images

Sample (50 ug of whole cell lysate). A: Mouse brain. 10% SDS PAGE. TA308027 diluted at 1:1000.

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  Sample (30 ug of whole cell lysate). A: Molt-4. B: Raji. 10% SDS PAGE. TA308027 diluted at 1:1000.

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  Immunohistochemical analysis of paraffin-embedded SAS xenograft, using ACMSD (TA308027) antibody at 1:100 dilution.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: IHC:1:100-1:1000; WB:1:500-1:3000
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant fragment corresponding to a region within amino acids 105 and 336 of ACMSD (Uniprot ID#Q8TDX5)
• Formulation: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Concentration: lot specific
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 38 kDa
• Gene Name: aminocarboxymuconate semialdehyde decarboxylase
• Database Link:
  NP_612199
  Entrez Gene 266645 MouseEntrez Gene 130013 Human
  UniProt ID Q8TDX5
• Background: The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS. [supplied by OMIM]
• Synonyms: 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; aminocarboxymuconate semialdehyde decarboxylase; OTTHUMP00000162500
• Note: Seq homology of immunogen across species: Bovine (93%)

Reference Data

• Protein Families: Transmembrane
• Protein Pathways: Metabolic pathways, Tryptophan metabolism