PTS Rabbit Polyclonal Antibody

CAT#: TA308040

Rabbit Polyclonal antibody to PTS (6-pyruvoyltetrahydropterin synthase)

Product Images

Sample (50 ug of whole cell lysate). A: mouse stomach. 15% SDS PAGE. TA308040 diluted at 1:1000.

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  Sample (30 ug of whole cell lysate). A: H1299. 15% SDS PAGE. TA308040 diluted at 1:1000.

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  Immunohistochemical analysis of paraffin-embedded Hepatoma, using PTS (TA308040) antibody at 1:500 dilution.

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  Immunofluorescence analysis of methanol-fixed HeLa, using PTS (TA308040) antibody at 1:100 dilution.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: ICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant fragment corresponding to a region within amino acids 1 and 145 of PTS (Uniprot ID#Q03393)
• Formulation: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Concentration: lot specific
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 16 kDa
• Gene Name: 6-pyruvoyltetrahydropterin synthase
• Database Link:
  NP_000308
  Entrez Gene 5805 Human
  UniProt ID Q03393
• Background: The enzyme encoded by this gene catalyzes the elimination of inorganic triphosphate from dihydroneopterin triphosphate, which is the second and irreversible step in the biosynthesis of tetrahydrobiopterin from GTP. Tetrahydrobiopterin, also known as BH(4), is an essential cofactor and regulator of various enzyme activities, including enzymes involved in serotonin biosynthesis and NO synthase activity. Mutations in this gene result in hyperphenylalaninemia. [provided by RefSeq]
• Synonyms: PTPS
• Note: Seq homology of immunogen across species: Bovine (84%)

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Folate biosynthesis, Metabolic pathways