MTGR1 (CBFA2T2) Rabbit Polyclonal Antibody

CAT#: TA308048

Rabbit polyclonal antibody to CBFA2T2 (core-binding factor, runt domain, alpha subunit 2; translocated to, 2)

Product Images

Sample (30 ug of whole cell lysate). A: Hep G2. 7.5% SDS PAGE. TA308048 diluted at 1:1000.

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  Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using CBFA2T2 (TA308048) antibody at 1:200 dilution.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: ICC/IF:1:100-1:1000; WB:1:500-1:3000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant fragment corresponding to a region within amino acids 401 and 604 of CBFA2T2 (Uniprot ID#O43439)
• Formulation: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 67 kDa
• Gene Name: CBFA2/RUNX1 translocation partner 2
• Database Link:
  NP_005084
  Entrez Gene 12396 MouseEntrez Gene 296293 RatEntrez Gene 9139 Human
  UniProt ID O43439
• Background: In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [provided by RefSeq]
• Synonyms: EHT; MTGR1; p85; ZMYND3
• Note: Seq homology of immunogen across species: Mouse (95%), Chicken (80%), Rat (95%)

Reference Data

• Protein Families: Transcription Factors