PANK1 Rabbit Polyclonal Antibody

CAT#: TA308055

Rabbit Polyclonal antibody to PANK1 (pantothenate kinase 1)

Product Images

Sample (50 ug of whole cell lysate). A: mouse liver. 10% SDS PAGE. TA308055 diluted at 1:1000.

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  Sample (30 ug whole cell lysate). A:Hep G2. 7.5% SDS PAGE. TA308055 diluted at 1:5000

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  Immunohistochemical analysis of paraffin-embedded NCIN87 xenograft, using PANK1 (TA308055) antibody at 1:500 dilution.

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  Immunofluorescence analysis of methanol-fixed Hep G2, using PANK1 (TA308055) antibody at 1:500 dilution.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: ICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:1000-1:10000
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant fragment corresponding to a region within amino acids 207 and 513 of PANK1 (Uniprot ID#Q8TE04)
• Formulation: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Concentration: lot specific
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 64 kDa
• Gene Name: pantothenate kinase 1
• Database Link:
  NP_612189
  Entrez Gene 75735 MouseEntrez Gene 294088 RatEntrez Gene 53354 Human
  UniProt ID Q8TE04
• Background: This gene encodes a protein belonging to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, have been identified. [provided by RefSeq]
• Synonyms: PANK
• Note: Seq homology of immunogen across species: Rat (98%)

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Metabolic pathways, Pantothenate and CoA biosynthesis