ORC2 Rabbit Polyclonal Antibody

CAT#: TA308075

Rabbit polyclonal antibody to ORC2 (origin recognition complex, subunit 2-like (yeast))

Product Images

Sample (30 ug of whole cell lysate). A: Raji. 7.5% SDS PAGE. ORC2 antibody. TA308075 diluted at 1:1000.

• 

  Immunohistochemical analysis of paraffin-embedded CL1-0 Xenograft, using ORC2 (TA308075) antibody at 1:100 dilution.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: IHC:1:100-1:1000; WB:1:500-1:3000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant fragment corresponding to a region within amino acids 208 and 479 of ORC2 (Uniprot ID#Q13416)
• Formulation: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Concentration: lot specific
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 66 kDa
• Gene Name: origin recognition complex subunit 2
• Database Link:
  NP_006181
  Entrez Gene 18393 MouseEntrez Gene 4999 Human
  UniProt ID Q13416
• Background: The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. This protein forms a core complex with ORC3L, -4L, and -5L. It also interacts with CDC45L and MCM10, which are proteins known to be important for the initiation of DNA replication. This protein has been demonstrated to specifically associate with the origin of replication of Epstein-Barr virus in human cells, and is thought to be required for DNA replication from viral origin of replication. [provided by RefSeq]
• Synonyms: ORC2L
• Note: Seq homology of immunogen across species: Mouse (84%), Bovine (92%)

Reference Data

• Protein Families: Stem cell - Pluripotency, Transcription Factors
• Protein Pathways: Cell cycle