ALAS2 Rabbit Polyclonal Antibody

CAT#: TA308176

Rabbit Polyclonal antibody to ALAS-E (aminolevulinate, delta-, synthase 2)

Product Images

Sample (30 ug of whole cell lysate). A: K562. 7.5% SDS PAGE. TA308176 diluted at 1:500.

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  Sample (50 ug of whole cell lysate). A: mouse liver. 7.5% SDS PAGE. TA308176 diluted at 1:1000.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB:1:500-1:3000
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant fragment corresponding to a region within amino acids 211 and 587 of ALAS-E (Uniprot ID#P22557)
• Formulation: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 65 kDa
• Gene Name: 5'-aminolevulinate synthase 2
• Database Link:
  NP_000023
  Entrez Gene 11656 MouseEntrez Gene 25748 RatEntrez Gene 212 Human
  UniProt ID P22557
• Background: The product of this gene specifies an erythroid-specific mitochondrially located enzyme. The encoded protein catalyzes the first step in the heme biosynthetic pathway. Defects in this gene cause X-linked pyridoxine-responsive sideroblastic anemia. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]
• Synonyms: ALAS-E; ALASE; ANH1; ASB; SIDBA1; XLDPP; XLEPP; XLSA
• Note: Seq homology of immunogen across species: Rat (95%), Xenopus laevis (81%), Zebrafish (80%), Bovine (95%), Xenopus tropicalis (81%)

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Glycine, serine and threonine metabolism, Metabolic pathways, Porphyrin and chlorophyll metabolism