CDC42 binding protein kinase alpha (CDC42BPA) Rabbit Polyclonal Antibody

CAT#: TA308303

Rabbit Polyclonal antibody to MRCK alpha (CDC42 binding protein kinase alpha (DMPK-like))

Product Images

MRCK alpha antibody detects CDC42BPA protein by Western blot analysis. A. 30 ug U87-MG whole cell lysate/extract. 5 % SDS-PAGE. MRCK alpha antibody (TA308303) dilution: 1:1000

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  Immunohistochemical analysis of paraffin-embedded SW480 xenograft, using MRCK alpha (TA308303) antibody at 1:100 dilution.

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  Immunofluorescence analysis of methanol-fixed HCT116, using MRCK alpha (TA308303) antibody at 1:500 dilution.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: ICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant fragment contain a sequence corresponding to a region within amino acids 373 and 564 of MRCK alpha
• Formulation: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Concentration: lot specific
• Purification: Affinity purified by Protein A.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 186 kDa
• Gene Name: CDC42 binding protein kinase alpha
• Database Link:
  NP_003598
  Entrez Gene 8476 Human
  UniProt ID Q5VT25
• Background: The protein encoded by this gene is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described, and the full-length nature of two of them has been reported. [provided by RefSeq]
• Synonyms: MRCK; MRCKA; PK428

Reference Data

• Protein Families: Druggable Genome, Protein Kinase