Melatonin Receptor 1A (MTNR1A) Rabbit Polyclonal Antibody

CAT#: TA308321

Rabbit polyclonal antibody to MEL-1A-R (melatonin receptor 1A)

Product Images

Melatonin Receptor 1A antibody detects Melatonin Receptor 1A protein by western blot analysis. Various whole cell extracts (30 ug) were separated by 10% SDS-PAGE, and the membrane was blotted with Melatonin Receptor 1A antibody (GTX100003) diluted at 1:1000.

Specifications

Product Data

• Applications: WB
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region within amino acids 80 and 172 of Melatonin Receptor 1A (Uniprot ID#P48039)
• Formulation: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Concentration: lot specific
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 39 kDa
• Gene Name: melatonin receptor 1A
• Database Link:
  NP_005949
  Entrez Gene 17773 MouseEntrez Gene 4543 Human
  UniProt ID P48039
• Background: This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin. [provided by RefSeq]
• Synonyms: MEL-1A-R; MT1
• Note: Seq homology of immunogen across species: Mouse (85%), Chicken (92%)

Reference Data

• Protein Families: Druggable Genome, GPCR, Transmembrane
• Protein Pathways: Neuroactive ligand-receptor interaction