PCCB Rabbit Polyclonal Antibody

CAT#: TA308402

Rabbit polyclonal antibody to PCCase beta (propionyl Coenzyme A carboxylase, beta polypeptide)

Product Images

Sample (30ug whole cell lysate). A: Hep G2. 7.5% SDS PAGE. TA308402 diluted at 1:1000

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  Immunohistochemical analysis of paraffin-embedded Lung Ad Cancer PC14 xenograft, using PCCB (TA308402 ) antibody at 1:100 dilution.

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  Immunofluorescence analysis of methanol-fixed Hep G2, using PCCB (TA308402) antibody at 1:500 dilution.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: ICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant fragment corresponding to a region within amino acids 167 and 480 of PCCB (Uniprot ID#P05166)
• Formulation: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Concentration: lot specific
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 58 kDa
• Gene Name: propionyl-CoA carboxylase beta subunit
• Database Link:
  NP_000523
  Entrez Gene 24624 RatEntrez Gene 66904 MouseEntrez Gene 5096 Human
  UniProt ID P05166
• Background: The protein encoded by this gene is a subunit of the propionyl-CoA carboxylase (PCC) enzyme, which is involved in the catabolism of propionyl-CoA. PCC is a mitochondrial enzyme that probably acts as a dodecamer of six alpha subunits and six beta subunits. This gene encodes the beta subunit of PCC. Defects in this gene are a cause of propionic acidemia type II (PA-2). [provided by RefSeq]
• Synonyms: DKFZp451E113
• Note: Seq homology of immunogen across species: Mouse (92%), Pig (94%), Rat (91%), Xenopus laevis (90%), Zebrafish (90%), Bovine (97%)

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Metabolic pathways, Propanoate metabolism, Valine, leucine and isoleucine degradation