PON2 Rabbit Polyclonal Antibody

CAT#: TA308448

Rabbit Polyclonal antibody to PON2 (paraoxonase 2)

Product Images

Sample (30 ug of whole cell lysate). A: A431. 10% SDS PAGE. PON2 antibody. TA308448 diluted at 1:1000.

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  Sample (50 ug of whole cell lysate). A: mouse liver. 10% SDS PAGE. TA308448 diluted at 1:1000.

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  Immunohistochemical analysis of paraffin-embedded N87 xenograft, using PON2 (TA308448) antibody at 1:100 dilution.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: IHC:1:100-1:1000; WB:1:500-1:3000
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant fragment corresponding to a region within amino acids 1 and 295 of PON2 (Uniprot ID#Q15165)
• Formulation: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Concentration: lot specific
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 39 kDa
• Gene Name: paraoxonase 2
• Database Link:
  NP_001018171
  Entrez Gene 296851 RatEntrez Gene 330260 MouseEntrez Gene 403855 DogEntrez Gene 5445 Human
  UniProt ID Q15165
• Background: This gene encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq]
• Synonyms: A-esterase 2; aromatic esterase 2; arylesterase 2; paraoxonase 2; paraoxonase nirs; serum aryldialkylphosphatase 2; serum paraoxonase
• Note: Seq homology of immunogen across species: Dog (92%), Pig (93%), Rat (90%), Bovine (92%)

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Metabolic pathways