DCK Rabbit Polyclonal Antibody

CAT#: TA308454

Rabbit Polyclonal antibody to DCK (deoxycytidine kinase)

Product Images

Sample (30 ug of whole cell lysate). A: A431. 12% SDS PAGE. TA308454 diluted at 1:5000.

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  DCK antibody detects DCK protein by western blot analysis. A. 50 ug mouse brain extract. 12 % SDS-PAGE. DCK antibody (TA308454) dilution: 1:1000

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  DCK antibody detects DCK protein by western blot analysis. A. 30 ug PC-12 whole cell extract. B. 30 ug Rat2 whole cell extract. 12 % SDS-PAGE. DCK antibody (TA308454) dilution: 1:1000

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  DCK antibody detects DCK protein at cytosol and nucleus on human lung carcinoma by immunohistochemical analysis. Sample: DCK antibody (TA308454) dilution: 1:250.

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  Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using Deoxycytidine kinase (TA308454) antibody at 1:200 dilution.

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Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: ICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:10000
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant fragment corresponding to a region within amino acids 1 and 260 of DCK (Uniprot ID#P27707)
• Formulation: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Concentration: lot specific
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 31 kDa
• Gene Name: deoxycytidine kinase
• Database Link:
  NP_000779
  Entrez Gene 13178 MouseEntrez Gene 1633 Human
  UniProt ID P27707
• Background: Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [provided by RefSeq]
• Synonyms: MGC117410; MGC138632

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Purine metabolism, Pyrimidine metabolism